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KMID : 0370220080520050361
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Yakhak Hoeji
2008 Volume.52 No. 5 p.361 ~ p.369
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The Cell Regenerative Effect of Benzoic Acid Derivatives Against Chomium Trioxide-Induced Cytotoxicity
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Han Du-Seok
Choi Byoung-Nam
Lee Jae-Sug
Choi Hwa-Jung
Baek Seung-Hwa
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Abstract
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In order to evaluate the cytotoxicity of chromium trioxide, and the cell regenerative effect of phenolic acid against chromium trioxide-induced cytotoxicity, cell viability, cell adhesion activity, lactate dehydrogenase (LDH) activity, and morphological changes of cells were performed in these cultures. The toxicity of chromium trioxide (IC50, 44.0 μM) was high according to the toxic criteria. Cell regeneration of benzoic acid derivatives against IC50 value of chromium trioxide in cell morphology was increased in concentration-dependent manner. These results suggest that benzoic acid derivatives may be used as a cell regenerative agent against chromium-ediated cytotoxicity.
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KEYWORD
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inhibitory effect, nickel-mediated cytotoxicity, cell viability, cell adhesion activity
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